Perturbed thyroid morphology and transient hypothyroidism symptoms inHoxa5 mutant mice
نویسندگان
چکیده
منابع مشابه
Congenital Hypothyroidism and Thyroid Cancer
Congenital hypothyroidism (CH) is a condition of thyroid hormone deficiency present at birth and can result in severe neurodevelopmental impairment, growth failure and permanent mental retardation if treatment is delayed for several months after birth (1-3). Girls are more frequently affected than boys (female to male ratios ranging from 2:1 to 4:1)(4). The mental retardation and neurodevelopme...
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Introduction: According to some studies, Ramadan fasting causes minimal changes in the levels of thyroid hormones. The present study aimed to evaluate the impact of Ramadan fasting on the levels of thyroid hormones in fasting women with hypothyroidism and levothyroxine intake. Methods: Serum levels of free thyroxine (T4) and thyroid-stimulating hormone (TSH) we...
متن کاملCongenital hypothyroidism and transient thyrotropin excess: differential diagnosis of abnormal newborn thyroid screening.
This article reviews the current knowledge of both transient and long term abnormalities of the newborn pituitary-thyroid axis. These defects are grouped according to their presenting characteristics in the neonatal screen ing programs. Some of the controversies regarding etiology, pathophysi ology, and possible treatments are discussed.
متن کاملPotent thyrotrophin receptor-blocking antibodies: a cause of transient congenital hypothyroidism and delayed thyroid development.
OBJECTIVE We describe an infant with surprisingly severe neonatal hypothyroidism due to transplacental passage of thyrotrophin receptor (TSH-R)-blocking antibodies (TBAb). DESIGN AND METHODS TBAb were detected using a cell line which stably expresses the human TSH-R and a cAMP-responsive luciferase reporter by their ability to inhibit TSH-stimulated luciferase expression. Potent TBAb were det...
متن کاملHypothyroidism, Particularly Associated with Weight Loss: Evaluation and Treatment based on Symptoms and Thyroid Hormone Levels
Famine causes adaptive changes in thyroid function which helped individuals survive during times of low food availability. These changes in thyroid function and metabolism have become maladaptive as the induced hypothyroidism associated with intentional weight loss restricts the success of diet attempts and encourages weight regain. In our previous paper we described the mechanisms and conseque...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2003
ISSN: 1058-8388,1097-0177
DOI: 10.1002/dvdy.10325